TheISO babban flangemisali ana kiransa LF, LFB, MF ko wani lokacin kawai ISO flange. Kamar yadda yake a cikin KF-flanges, flanges suna haɗuwa da zobe na tsakiya da o-ring na elastomeric. Ana amfani da ƙarin madaurin madauwari mai ɗorewa sau da yawa a kusa da manyan zoben o-ring don hana su jujjuyawa daga zoben tsakiya yayin hawa.

Manyan flanges na ISO sun zo cikin iri biyu. An haɗa flanges na ISO-K (ko ISO LF) tare da ƙugiya mai kauri biyu, waɗanda ke manne zuwa madauwari tsagi a gefen tubing na flange. Wuraren ISO-F (ko ISO LFB) suna da ramuka don haɗa flanges biyu tare da kusoshi. Ana iya haɗa bututu guda biyu tare da flanges na ISO-K da ISO-F tare ta hanyar matse gefen ISO-K tare da matsi guda ɗaya, waɗanda sannan a kulle su zuwa ramukan da ke gefen ISO-F.

ISO manyan flanges suna samuwa a cikin masu girma dabam daga 63 zuwa 500 mm diamita na bututu mara kyau.